Can you eat grapefruit while taking Depakote?

Can you eat grapefruit while taking Depakote?

Can you eat grapefruit while taking Depakote?

Drug and food interactions Do not consume grapefruit or grapefruit juice during treatment with quiNIDine unless specifically directed otherwise by your doctor.

How long does Depakote stay in your system?

When taken by itself, the half-life of Depakote is roughly 14 hours, and it takes five half-lives to eliminate most drugs. So, while the levels of Depakote may not be high enough to have clinical effects, Depakote can remain in your system for about three days following a single dose.

What should not be taken with Depakote?

Some products that may interact with this drug include: certain antidepressants (e.g., amitriptyline, nortriptyline, phenelzine), certain antibiotics (carbapenems such as doripenem, imipenem), irinotecan, mefloquine, orlistat, other medications for seizure (e.g., ethosuximide, lamotrigine, phenytoin, rufinamide, ...

What should I eat with Depakote?

Depakote Sprinkle Capsules (for epilepsy only) may be swallowed whole or opened and the contents sprinkled on soft food. The food with the drug should be eaten immediately without chewing. You must eat all of the food to get your full dose of medicine.

Why is it bad to take grapefruit juice with medication?

Many drugs are broken down (metabolized) with the help of a vital enzyme called CYP3A4 in the small intestine. Grapefruit juice can block the action of intestinal CYP3A4, so instead of being metabolized, more of the drug enters the blood and stays in the body longer.

How much grapefruit juice does it take to affect medications?

One whole grapefruit or one glass of grapefruit juice is enough to alter how these medications affect you. Its effects last several days. Grapefruit's ability to affect medication lasts for 1–3 days. Taking your medication a few hours apart from consuming it isn't long enough.

How can I avoid weight gain on Depakote?

Here are some ways to lose weight gained due to medication use:

  1. Switch to a different medication. The first strategy to consider involves changing medications. ...
  2. Lower medication dosage. ...
  3. Limit portion sizes. ...
  4. Exercise. ...
  5. Eat more protein. ...
  6. Talk to a dietitian. ...
  7. Avoid alcohol. ...
  8. Get enough sleep.

Can you take Depakote long term?

To date, there are no known problems associated with long term use of valproate. It is a safe and effective medication when used as directed.

Are there any drug interactions between grapefruit and Depakote?

  • We study 5,707 people who take Depakote er or Grapefruit. There is no drug interaction reported. The phase IV clinical study analyzes what interactions people who take Depakote er and Grapefruit have. It is created by eHealthMe based on reports the from the FDA, and is updated regularly.

Is it dangerous to eat a grapefruit while taking medication?

  • Yes. Grapefruit and certain other citrus fruits, such as Seville oranges, can interfere with several kinds of prescription medications. Don't take these interactions lightly. Some can cause potentially dangerous health problems.

Is it safe to eat grapefruit while on bipolar medication?

  • Unlike some types of citrus fruit, grapefruit can interfere with the metabolization of certain drugs, inadvertently increasing their concentration to potentially toxic levels. Bipolar drugs are not the only ones affected.

How does grapefruit juice and medications work together?

  • How grapefruit juice and medications interact depends on a variety of factors, especially the amount of CYP3A4 in the body. That’s why the impact and side effects of this interaction vary from patient to patient. Canadian researchers have identified at least 85 drugs that may interact with grapefruit juice.

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